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  • Bosentan 62.5MG
  • Bosentan 125MG

Bosentan tablets have been approved by the FDA for the treatment of pulmonary arterial hypertension (PAH). This drug is indicated for use in improving exercise ability and decreasing the rate of clinical worsening in patients with WHO Class III or IV symptoms. Tracleer 125 mg (taken twice a day) is the first approved oral treatment for patients with PAH.

Tracleer belongs to a class of drugs known as endothelin receptor antagonists (ERAs). Patients with PAH have elevated levels of endothelin, a potent blood vessel constrictor, in their plasma and lung tissue. Tracleer blocks the binding of endothelin to its receptors, thereby negating endothelin's deleterious effects.